Not Losing Weight on Mounjaro? Here’s Why + Solutions!

Mounjaro has become a popular injectable medication for weight loss, but even with its appetite-suppressing effects, some people find themselves frustrated by a lack of results.

If you’re wondering “Why am I not losing weight on Mounjaro,” you’re not alone.

Our goal is to help you understand your weight loss journey better and make informed decisions about your health and lifestyle.

Whether you’re a Mounjaro user struggling with weight loss or someone considering this method, this post is for you. Let’s dive in!

What is Mounjaro?

Mounjaro, chemically known as tirzepatide, is an injectable medication that was initially approved by the FDA in 2022 to treat Type 2 diabetes.

It’s now gaining attention for its potential in aiding weight loss.

How Does Mounjaro Aid in Weight Loss?

Mounjaro works by uniquely activating two receptors simultaneously. It targets GLP-1, a hormone released from your digestive tract that helps lower blood sugar and promotes a feeling of fullness.

It also influences another hormone that stimulates the release of insulin.

This dual-action not only helps manage blood sugar levels but also aids in weight management by making you feel fuller faster.

In clinical trials, people with diabetes experienced significant weight loss after taking Mounjaro compared to those taking a placebo.

The drug’s ability to improve weight management prompted researchers to evaluate it in separate studies with people who are obese or overweight.

In one study, individuals who received the highest dose (15 milligrams once weekly) lost an average of 18% of their body weight compared to those taking a placebo.

Based on these study results, the FDA approved Zepbound (another name for Mounjaro when used for weight loss) in November 2023 for adults with obesity or overweight with at least one weight-related condition, such as high blood pressure, Type 2 diabetes, or high cholesterol.

Personal Experiences and Challenges

While many people have found success with Mounjaro, there are also those who haven’t seen the expected weight loss.

Here are some personal experiences:

  • A user on Reddit shared their experience after 6 weeks on Mounjaro. Despite having a strict diet and exercise regimen, they only lost a small amount of weight. They experienced headaches and had to increase their intake of electrolytes.
  • Another individual, a 61-year-old woman, managed to lose 75 pounds after thyroid removal with the help of Mounjaro. However, she emphasized that it was a combination of Mounjaro, a low carbohydrate diet, and regular walking that led to her weight loss.
  • Some users have reported feeling full and uncomfortable if they overeat while on Mounjaro.

Emotional Impact and Disappointment

Not seeing the expected weight loss results can lead to feelings of frustration and disappointment.

This can be particularly challenging for individuals who have struggled with weight loss for a long time and have high hopes for Mounjaro.

  • Emotional eating can sabotage weight loss efforts. If individuals find themselves turning to food for comfort or as a coping mechanism, it’s important to address the underlying emotional triggers.
  • Mood fluctuations have been a concern for some users. About 22% of study participants mentioned feelings of irritability, anxiety, and mood swings.
  • If individuals have historically been ‘emotional eaters’ and find they reach for food when feeling sad or stressed, these cravings may still occur on Mounjaro.

Common Reasons for Not Losing Weight on Mounjaro

Inaccurate Calorie Tracking

One of the most common reasons for not losing weight, even when using Mounjaro, is inaccurate calorie tracking.

It’s crucial to accurately track both your calorie intake and expenditure to create a calorie deficit, which is necessary for weight loss.

If you’re consuming more calories than you’re burning, you won’t lose weight, regardless of the medication you’re taking.

Using a food diary or a calorie-tracking app can help ensure that you’re accurately tracking your calories.

Lack of Physical Activity

Regular physical activity is crucial for weight loss. It helps burn calories, increases metabolism, and enhances overall health.

If you’re not engaging in regular physical activity, it can hinder your weight loss progress, even if you’re on Mounjaro.

Incorporating regular exercise into your routine, whether it’s walking, running, swimming, or strength training, can significantly aid in weight loss.

Medical Conditions

Certain medical conditions, such as hypothyroidism, Polycystic Ovary Syndrome (PCOS), and insulin resistance, can affect weight loss.

These conditions can slow down metabolism, increase appetite, or cause the body to store fat, making weight loss more challenging.

If you have any of these conditions and are struggling to lose weight on Mounjaro, it’s important to consult with a healthcare professional.

Emotional Eating

Emotional eating, or the tendency to eat in response to stress, sadness, or other emotions, can sabotage weight loss efforts.

Even if you’re taking Mounjaro, emotional eating can still cause you to eat more calories than you burn.

It’s important to recognize and address emotional eating habits and find healthier ways to cope with emotions.

Inadequate Sleep

Lack of sleep can hinder weight loss progress. When you’re sleep-deprived, your body produces more of the hunger hormone ghrelin, which can lead to increased appetite.

Additionally, lack of sleep can affect your energy levels, making it harder to engage in physical activity.

Ensuring you get adequate sleep is an important part of a successful weight loss journey.

Solutions and Recommendations

Here are some solutions to the challenges mentioned above:

Accurate Calorie Tracking

Using a food diary or a calorie-tracking app can help ensure that you’re accurately tracking your calories.

These tools can provide insights into your eating habits and help you make necessary adjustments to create a calorie deficit, which is essential for weight loss.

Regular Physical Activity

Adding regular exercise to your routine can greatly help with weight loss. This can include activities like walking, running, swimming, or strength training.

Choose something you enjoy and can continue doing over time.

Consulting with a Healthcare Professional

If you have underlying medical conditions that are making weight loss more challenging, it’s important to consult with a healthcare professional.

They can provide personalized advice and treatment options based on your specific needs and conditions.

Managing Emotional Eating

Recognizing and addressing emotional eating habits is crucial for successful weight loss.

This could involve finding healthier ways to cope with emotions, such as engaging in a hobby, practicing mindfulness, or seeking support from a mental health professional.

Prioritizing Adequate Sleep

Ensuring you get adequate sleep is an important part of a successful weight loss journey.

Establish a regular sleep schedule, create a relaxing bedtime routine, and make your sleep environment comfortable and conducive to good sleep.

Adjusting Mounjaro Dosage

Some users have reported better results with higher doses of Mounjaro.

However, any changes to medication dosage should be done under the supervision of a healthcare professional.

If you’re not seeing the expected weight loss results with Mounjaro, it may be worth discussing the possibility of increasing the dosage with your healthcare provider.


Why am I gaining weight on Mounjaro?

There could be several reasons for weight gain while using Mounjaro. Some users have reported weight gain after switching from other medications like Ozempic. It’s also possible that some of the weight gain is due to water retention.

Is it normal to gain weight when starting Mounjaro?

Some users have reported initial weight gain or fluctuation when starting Mounjaro. However, this is not a universal experience and can vary from person to person.

Can I do strength/weight training while on Mounjaro?

Yes, many users have reported being able to continue their strength/weight training while on Mounjaro. Some users have reported needing to adjust their routine or take longer breaks during their workouts.

Will I regain weight after stopping Mounjaro?

Based on data from a randomized controlled trial (RCT), you’ll likely regain some of the weight you lose on Mounjaro after stopping the treatment if you haven’t made the necessary lifestyle changes to help you maintain weight loss.

How much weight can I expect to lose on Mounjaro?

Researchers have shown that Mounjaro can significantly lower weight in people with obesity. In a study of more than 2,500 adults with obesity, people taking 5 milligrams of Mounjaro for 72 weeks (about a year and a half) lost 15% of their body weight on average.


Remember, weight loss is a journey that takes patience and perseverance. It’s not about quick fixes; it’s about making lasting changes to your lifestyle.

Always consult with a healthcare professional before starting any new medication or weight loss program.

Your health and well-being are worth the effort, and every step you take towards a healthier lifestyle is a step in the right direction. Keep going!


Hi there, I'm Pranay, a fitness enthusiast who loves working out regularly and staying in shape. I'm passionate about health and fitness, and I'm always on the lookout for new and exciting ways to stay active and healthy.

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